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mitotane decreases levels of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a solid inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for achievable dosage changes.
An alternate drug is favored, Specially while nursing a new child or preterm toddler. If etizolam is used, keep track of the toddler for sedation, very poor feeding and inadequate excess weight gain.
The blood amounts of ergotamine-made up of prescription drugs are reported being elevated from the concomitant administration of macrolide antibiotics and vasospastic reactions have been noted with therapeutic doses of your ergotamine-that contains drugs when coadministered Using these antibiotics.
clarithromycin improves toxicity of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration may end in vasospasm and ischemia on the extremities and various tissues such as the CNS.
Contraindicated (one)procarbazine improves consequences of caffeine by pharmacodynamic synergism. Contraindicated. Caffeine can produce severe hypertensive crises or unsafe cardiac arrhythmias if administered to individuals get more info getting a MAOI.
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efavirenz will lower the level or result of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
isavuconazonium sulfate will enhance the level or result of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
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